MAGNESIUM

[1] RCT found that magnesium can reduce severity of menstrual symptoms such as dysmenorrhea. Magnesium has further been shown to reduce pain intensity and menstrual bleeding.

[2] Clinical research demonstrates that magnesium supplementation can effectively reduce menstrual cramps (dysmenorrhea) and related-period symptoms

[3] A randomized controlled trial found that magnesium significantly decreased the severity of cramps, headaches, back pain, abdominal pain, and mood symptoms like depression and irritability

[4] Multiple studies have established a positive correlation between magnesium and relief from premenstrual symptoms and dysmenorrhea, suggesting that magnesium supplementation represent a valid treatment option for managing these common menstrual symptoms

Arnica

[1] Arnica Montana is widely used for its anti-inflammatory properties and has been shown to be more effective than placebo for reducing post-traumatic and postoperative pain, swelling, and bruising. It has demonstrated pain-relieving effects comparable to medications like ibuprofen and diclofenac in conditions such as arthritis and post-operative recovery.

Iron Powder

Note: There is strong scientific support for relieving women's discomfort using heat therapy generated by iron-powder technology

[1] A randomized controlled trial of 147 women compared iron chip heat patches with ibuprofen for treating primary dysmenorrhea. The study found that heat patches provided pain relief comparable to ibuprofen at 8, 12, and 24 hours, with no significant differences between groups. The patches self-heated through iron oxidation and maintained a therapeutic temperature (around 40°C) for up to 8 hours, offering an effective non-drug option for menstrual cramp relief.

[2] RCT in women found that continuous low-level topical heat (waist or lower-abdomen wrap) was as effective as ibuprofen (400 mg TID) for relief of pain over the first 8 hours of treatment

[3] Another RCT found heat wraps superior to acetaminophen for pain relief and for cramping/tightness over an 8-hour observation

Menthol

[1] A study on peppermint extract (which contains menthol) found that is significantly reduced menstrual pain, symptom severity, and other clinical signs of dysmenorrhea.

[2] Research has been found that a topical cream containing menthol provided cooling pain relief and muscle relaxation. The mechanism of action for menthol in this study included:

• Localized pain relief by activating TRPM8 cold receptors and blocking calcium entry into nerve cells to reduce nerve excitability
• Blocks pain signals - prevents calcium from entering nerve cells
• Reduces inflammation - lowers pro-inflammatory molecules while increasing anti-inflammatory factors
• Relaxes uterine muscles
• Eases digestive symptoms - helps with period-related nausea, vomiting, and diarrhea by relaxing intestinal muscles
• Works through the skin - penetrates through skin layers to reach the underlying tissues and provide targeted relief

[2] A 2018 systematic review of over 30 scientific studies were done to show how menthol helps to relieve pain when applied to the skin.

• It activates TRPM8 receptors that produce cooling sensations
• Works as a counter-irritant, and can desensitize pain receptors over time
• Menthol may also activate central pain-relief pathways.

Lavender

[1] Lavender essential oil has been noted in dermatology-focussed reviews for its antimicrobial, anti-inflammatory, and wound-healing properties

[2] Evidence suggests lavender essential oil can help support skin repair processes and promote a healthier skin surface environment

[3] In early-stage studies lavender is recognized as a botanical that can to help soothe and support stressed or irritated skin

[4] Clinical trials show that lavender can help reduce stress and anxiety, supporting feelings of calm and relaxation

Raspberry Leaf

[1] Raspberry leaf is traditionally known as a women’s wellness herb, often recommended for PMS symptoms like cramping, nausea, and digestive upset. Herbalists attribute these effects to fragarine, which may help tone pelvic muscles, and tannins, which may support uterine strength and reduce heavy or irregular bleeding. Though widely used and referenced in herbal handbooks, there are no clinical studies confirming its effectiveness for period cramps specifically

[2] Research shows raspberry leaves are rich in antioxidants, vitamins, and minerals, including vitamin C, vitamin E, magnesium, calcium, and zinc. Lab and comparison studies consistently report strong antioxidant capacity in raspberry leaves, sometimes even higher than the fruit itself. These antioxidant effects have been linked in reviews to anti-inflammatory activity and potential metabolic benefits.

[3] Early scientific studies suggest broader health benefits, including anti-inflammatory effects, and promising skin benefits when used in topical formulations.

Magnesium

[1] Double blind RCTs in women with primary dysmenorrhea found that magnesium reduced pain intensity (specifically lower back pain and lower abdominal pain) and the need for analgesics compared with placebo

[2] A 2024 narrative review of magnesium in chronic pain reports "good evidence" for magnesium in certain chronic pain conditions, including renal colic pain and pelvic pain related to endometriosis, based on RCTs where magnesium was used as an adjunct analgesic

Arnica

[1] Arnica Montana is widely used for its anti-inflammatory properties and has been shown to be more effective than placebo for reducing post-traumatic and postoperative pain, swelling, and bruising. It has demonstrated pain-relieving effects comparable to medications like ibuprofen and diclofenac in conditions such as arthritis and post-operative recovery.

Iron Powder

Note: There is strong scientific support for relieving women's discomfort using heat therapy generated by iron-powder technology

[1] RCT in women found that continuous low-level topical heat (waist or lower-abdomen wrap) was as effective as ibuprofen (400 mg TID) for relief of pain over the first 8 hours of treatment

[2] Another RCT found heat wraps superior to acetaminophen for pain relief and for cramping/tightness over an 8-hour observation

Sweet Orange

[1] Women (aged 22-57) had lower state of anxiety, more positive mood, and higher level of calmness when exposed to smell of sweet orange odor

[2] Orange essential oil enhanced spatial working memory (included choice reaction time accuracy, the quality of memory as indicated by reaction time of word recognition) as well as alertness and calmness

[3] When used topically, sweet orange acts as penetration enhancers exhibiting radial scavenging activity, reducing oxidative stress and inflammation. This essential oil further had an antimicrobial against bacteria and fungi (suggesting benefits for skin hygiene). Additionally provides protection from UV-induced oxidative damage

[4] Studies find that sweet orange carries anti-inflammatory, antimicrobial, antioxidant effects in skin. Studies further suggest reduction of skin inflammation and redness along with proection against oxidative skin damage

[5] A 2020 study examining essential oils for acne found that sweet orange essential oil demonstrated several beneficial effects on acne-related skin changes

Magnesium

[1] A 2025 review highlights that magnesium plays an important role in maintaining overall skin health, particularly under conditions of oxidative stress or when magnesium levels are low

[2] This same study shows that magnesium supports skin barrier function, helps regulate inflammatory responses, and contributes to skin repair and regeneration, all of which promote stronger, more resilient skin

Hyaluronic Acid

[1] A 2022 review found that HA-based skincare products offer a non-invasive and effective way to boost moisture, support skin structure, and enhance overall skin appearance

[2] A clinical study using HA applied to crows feet and wrinkles improved skin hydration and wrinkle depth (34 subjects, twice weekly for 8 weeks)

[3] Additional research shows that HA is clinically associated with anti-aging, moisturizing, anti-inflammatory, and skin-healing benefits, reinforcing its role as a powerful hydrator that helps keep the skin smooth, plump, and resilient

Plant-Based Collagen

[1] Collagen supplementation shows statistically significant improvements in skin hydration and elasticity vs placebo. A systematic review of 26 RCT (n=1,271) found improved hydration and elasticity.

[2] A clinical study of a native collagen sheet mask (>62% bovine collagen) found improvements in skin hydration, wrinkle volume, skin roughness compared to a cellulose sheet mask

[3] A randomized triple-blind study of a freshwater marine collagen supplement found wrinkle/elasticity improvements in women aged 45-60

Green Apple Stem Cell

[1] A clinical study investigated the anti-aging effects of a cream containing apple stem cell extract applied twice daily for 28 days to the crow’s-feet area in 20 women aged 37-64. Skin evaluation using 3D imaging showed a 15% reduction in wrinkle depth after four weeks, with no reported irritation or adverse effects